Currently Vanilla-WP runs with WP-Super-Cache enabled, and my abandoned Database Cache disabled. The fun part of WP-Super-Cache as caching plugin is, it allows the usage of plugins. Yes, a plugin for a plugin 🙂 . One of those plugins is WPSCMin, by Joel Hardi.
After enabling WinCache as an object cache back-end, and OPCache for opcode caching, WordPress performance can be further improved by adding a database cache.
32 queries, took 0.101 seconds running PHP version 7.2.15